Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239109 | 0.94 | CNR2 (0.37) | LMNAMAPTTP53CNR2HRH3 | |
| SCHEMBL6922373 | 0.91 | MAPT (0.37) | LMNAMAPTTP53CNR2HRH3 | |
| SCHEMBL6923220 | 0.89 | MAPT (0.36) | MAPTCNR2HRH3GSK3BDYRK1A | |
| SCHEMBL14240248 | 0.87 | SMO (0.36) | CNR2HRH3GSK3BDYRK1ATGFBR1 | |
| SCHEMBL6920417 | 0.86 | NPC1 (0.41) | LMNAMAPTTP53GSK3BDYRK1A | |
| SCHEMBL14239310 | 0.85 | METAP2 (0.38) | CNR2HRH3GSK3BDYRK1ATGFBR1 | |
| SCHEMBL14239107 | 0.83 | USP30 (0.35) | LMNAMAPTTP53CNR2HRH3 | |
| SCHEMBL14238856 | 0.83 | METAP2 (0.34) | CNR2HRH3GSK3BDYRK1ATGFBR1 | |
| SCHEMBL14239108 | 0.82 | SMO (0.39) | LMNATP53CNR2HRH3GSK3B | |
| SCHEMBL14239044 | 0.82 | TGFBR1 (0.36) | LMNATP53CNR2HRH3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170845-A2 | METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | HEFFERNAN MICHELE L R (US) | 2012-12-13 | — | — | WO | disclosed |