Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14238871 | 0.84 | L3MBTL1 (0.50) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL14238901 | 0.83 | TDP1 (0.42) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL6922412 | 0.83 | NPC1 (0.45) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL6921641 | 0.82 | USP30 (0.42) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL14239809 | 0.82 | TDP1 (0.39) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL18037016 | 0.82 | TDP1 (0.39) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL14239920 | 0.81 | USP30 (0.42) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL14239922 | 0.80 | USP30 (0.41) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL14239414 | 0.77 | NPC1 (0.40) | TDP1L3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL6921956 | 0.77 | RAB9A (0.45) | TDP1L3MBTL1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170845-A2 | METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | HEFFERNAN MICHELE L R (US) | 2012-12-13 | — | — | WO | disclosed |