SCHEMBL1423958

SCHEMBL1423958

CN(C)c1cccc(C=CC(=O)O)c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.57
HDAC4 P56524 4/20 0.55
HDAC3 O15379 3/20 0.55
HDAC1 Q13547 3/20 0.55
HDAC7 Q8WUI4 3/20 0.55
HDAC2 Q92769 3/20 0.55
HDAC10 Q969S8 3/20 0.55
HDAC11 Q96DB2 3/20 0.55
HDAC8 Q9BY41 3/20 0.55
HDAC6 Q9UBN7 3/20 0.55
HDAC9 Q9UKV0 3/20 0.55
HDAC5 Q9UQL6 3/20 0.55
TNKS O95271 1/20 0.55
HCAR2 Q8TDS4 1/20 0.55
TNKS2 Q9H2K2 1/20 0.55
KDM4E B2RXH2 4/20 0.53
ALDH1A1 P00352 4/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
MEF2D Q14814 1/20 0.52
MAPT P10636 4/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8053440 1.00 NPSR1 (0.57) NPSR1HDAC4HDAC3HDAC1HDAC7
SCHEMBL10717371 0.88 HSD17B3 (0.62) NPSR1HDAC4HDAC3HDAC1HDAC7
SCHEMBL7317275 0.86 TDP1 (0.56) NPSR1HDAC4HDAC3HDAC1HDAC7
SCHEMBL7317282 0.86 TDP1 (0.56) NPSR1HDAC4HDAC3HDAC1HDAC7
SCHEMBL12425722 0.82 HDAC4 (0.69) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL69146 0.81 NPSR1 (0.74) NPSR1HDAC4HDAC3HDAC1HDAC7
SCHEMBL271386 0.81 NPSR1 (0.74) NPSR1HDAC4HDAC3HDAC1HDAC7
SCHEMBL14619147 0.80 CYP3A4 (0.53) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL782211 0.80 HDAC4 (0.47) HDAC4HDAC3HDAC1HDAC7HDAC2
SCHEMBL782212 0.80 HDAC4 (0.47) HDAC4HDAC3HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7018765-B2 Toner particle having a hardnes of 6.0 to 24.0 mN and a circularity of 0.92 to 0.99 KONICA CORPORATION (JP) 2006-03-28 US claimed
EP-1662328-B1 Image forming method KONICA MINOLTA BUSINESS TECH (JP) 2012-04-25 EP disclosed
EP-1653289-B1 Image forming method KONICA MINOLTA BUSINESS TECH (JP) 2011-03-23 EP disclosed
US-7846626-B2 Image forming method and image forming apparatus KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) 2010-12-07 US disclosed
US-20100086795-A1 RADIATION IMAGE CONVERSION PANEL KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2010-04-08 US disclosed
US-7645457-B2 Emulsified cosmetics FUJI XEROX CO., LTD. (JP) 2010-01-12 US disclosed
US-7531282-B2 Organic photoreceptor, image forming apparatus, image forming method and process cartridge KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) 2009-05-12 US disclosed
US-7517629-B2 Image forming method KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) 2009-04-14 US disclosed
US-7466326-B2 Image forming method and image forming apparatus KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) 2008-12-16 US disclosed
US-7344815-B2 Toner for forming electrostatic image KONICA CORPORATION (JP) 2008-03-18 US disclosed
US-20030027072-A1 Electrostatic image developing toner and image forming method KONICA CORPORATION (JP) 2003-02-06 US disclosed
US-20020192582-A1 Latent image formed on a latent image forming body employing exposure is subjected to reversal development employing a developer comprising toner to form an image KONICA CORPORATION (JP) 2002-12-19 US disclosed
US-20020142243-A1 Toner for forming electrostatic image KONICA CORPORATION (JP) 2002-10-03 US disclosed
US-20020136976-A1 Electrostatic image developing KONICA CORPORATION (JP) 2002-09-26 US disclosed
US-20020110745-A1 Toner for developing static latent image to form color image KONICA CORPORATION (JP) 2002-08-15 US disclosed
US-6255029-B1 Process for preparing a color toner for developing an electrostatic image KONICA CORPORATION (JP) 2001-07-03 US disclosed
US-6248494-B1 COLORED PARTICLES COMPRISING RESIN AND COLORANT; SHAPE COEFFICIENT; ELECTROGRAPHY KONICA CORPORATION 2001-06-19 US disclosed
US-6143762-A DRUGS AS DOPAMINE ANTAGONIST PSYCHOLOGICAL DISORDERS SMITHKLINE BEECHAM, PLC (GB) 2000-11-07 US disclosed
EP-0922035-A1 TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE SMITHKLINE BEECHAM PLC (GB) 1999-06-16 EP disclosed
WO-1998006699-A1 TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE SMITHKLINE BEECHAM PLC (GB) 1998-02-19 WO disclosed