Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 2/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.30 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.30 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.30 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.30 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14242893 | 0.87 | CSNK2B (0.40) | CSNK2BCSNK2A1CSNK2A2TYK2TTK | |
| SCHEMBL14243124 | 0.77 | CSNK2B (0.48) | CSNK2BCSNK2A1CSNK2A2CDK2CCNA2 | |
| SCHEMBL14242544 | 0.76 | CSNK2B (0.51) | CSNK2BCSNK2A1CSNK2A2CDK2TYK2 | |
| SCHEMBL14242539 | 0.76 | CSNK2B (0.44) | CSNK2BCSNK2A1CSNK2A2CDK2TYK2 | |
| SCHEMBL14243301 | 0.76 | CSNK2B (0.48) | CSNK2BCSNK2A1CSNK2A2CDK2TYK2 | |
| SCHEMBL14243294 | 0.76 | CSNK2B (0.45) | CSNK2BCSNK2A1CSNK2A2CDK2TYK2 | |
| SCHEMBL14242500 | 0.73 | CSNK2B (0.38) | CSNK2BCSNK2A1CSNK2A2CDK2TYK2 | |
| SCHEMBL14242464 | 0.73 | CSNK2B (0.44) | CSNK2BCSNK2A1CSNK2A2CDK2TYK2 | |
| SCHEMBL14242503 | 0.70 | CSNK2B (0.38) | CSNK2BCSNK2A1CSNK2A2CDK2CHEK1 | |
| SCHEMBL14158133 | 0.70 | CSNK2B (0.38) | CSNK2BCSNK2A1CSNK2A2CDK2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170827-A2 | PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |