⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL8988620 | 0.79 | — | — | |
| SCHEMBL25366237 | 0.79 | — | — | |
| SCHEMBL30655945 | 0.74 | CA1 (0.33) | — | |
| SCHEMBL145452 | 0.74 | CA1 (0.33) | — | |
| SCHEMBL776698 | 0.74 | CA1 (0.33) | — | |
| SCHEMBL14669110 | 0.74 | CA1 (0.33) | — | |
| Ammonia Solution, Strong SCHEMBL28986371 | 0.72 | CA1 (0.32) | — | |
| SCHEMBL26137572 | 0.72 | ALDH1A1 (0.39) | — | |
| SCHEMBL28525194 | 0.72 | CA1 (0.32) | — | |
| Iodide SCHEMBL7252284 | 0.72 | CA1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230255922-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2023-08-17 | — | — | US | disclosed |
| US-11672775-B2 | Treprostinil prodrugs | UNITED THERAPEUTICS CORPORATION (US) | 2023-06-13 | — | — | US | disclosed |
| CN-113637009-B | Method for preparing aza-heterocyclic compound | 华中科技大学 | 2023-03-28 | — | — | CN | disclosed |
| CN-113637009-A | Method for preparing aza-heterocyclic compound | 华中科技大学 | 2021-11-12 | — | — | CN | disclosed |
| US-20210121433-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2021-04-29 | — | — | US | disclosed |
| EP-3461817-B1 | POTASSIUM SALT OF BERAPROST | LUNG BIOTECHNOLOGY INC (US) | 2020-11-04 | — | — | EP | disclosed |
| CN-108137545-B | Triazole agonists of the APJ receptor | 美国安进公司 | 2020-09-22 | — | — | CN | disclosed |
| US-10710973-B2 | Method of producing beraprost | LUNG BIOTECHNOLOGY PBC (US) | 2020-07-14 | — | — | US | disclosed |
| EP-3515430-A1 | TREPROSTINIL PRODRUGS | United Therapeutics Corporation (US) | 2019-07-31 | — | — | EP | disclosed |
| US-20190194156-A1 | METHOD OF PRODUCING BERAPROST | LUNG BIOTECHNOLOGY PBC (US) | 2019-06-27 | — | — | US | disclosed |
| US-20170158658-A1 | METHOD OF PRODUCING BERAPROST | LUNG BIOTECHNOLOGY PBC (US) | 2017-06-08 | — | — | US | disclosed |
| US-9611243-B2 | Method of producing beraprost | LUNG BIOTECHNOLOGY PBC (US) | 2017-04-04 | — | — | US | disclosed |
| US-20160244422-A1 | METHOD OF PRODUCING BERAPROST | LUNG BIOTECHNOLOGY PBC (US) | 2016-08-25 | — | — | US | disclosed |
| US-9334255-B2 | Method of producing beraprost | LUNG BIOTECHNOLOGY PBC (US) | 2016-05-10 | — | — | US | disclosed |
| US-9181212-B2 | Method of producing beraprost | LUNG BIOTECHNOLOGY PBC (US) | 2015-11-10 | — | — | US | disclosed |
| US-20150183757-A1 | METHOD OF PRODUCING BERAPROST | LUNG BIOTECHNOLOGY INC. (US) | 2015-07-02 | — | — | US | disclosed |
| US-20140275573-A1 | METHOD OF PRODUCING BERAPROST | LUNG BIOTECHNOLOGY INC. (US) | 2014-09-18 | — | — | US | disclosed |
| US-8779170-B2 | Method of producing beraprost | LUNG BIOTECHNOLOGY INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130210851-A1 | Crystalline forms of a hexahydrofuro[3,4-c]quinoline derivative | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20120323025-A1 | METHOD OF PRODUCING BERAPROST | Lung LLC | 2012-12-20 | — | — | US | disclosed |