Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.57 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | IL1B | P01584 | 1/20 | 0.51 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 6/20 | 0.46 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4986366 | 0.89 | CRBN (0.53) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL14072368 | 0.85 | CRBN (0.63) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL1424618 | 0.84 | CRBN (0.59) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL4564524 | 0.84 | CRBN (0.60) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL1963474 | 0.84 | CRBN (0.74) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL1424862 | 0.83 | CRBN (0.59) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL4997427 | 0.83 | CRBN (0.56) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL12811057 | 0.82 | CRBN (0.53) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL1424884 | 0.82 | CRBN (0.57) | CRBNIKZF1CSNK1A1IKZF3DDB1 | |
| SCHEMBL1961945 | 0.82 | CRBN (0.64) | CRBNIKZF1CSNK1A1IKZF3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076260-B1 | N-METHYLAMINOMETHYL ISOINDOLE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2011-03-23 | — | — | EP | disclosed |