Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.74 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.74 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.74 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.62 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | TNF | P01375 | 1/20 | 0.62 |
| ▸ | IL1B | P01584 | 1/20 | 0.62 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.52 |
| ▸ | MAP1LC3B | Q9GZQ8 | 7/20 | 0.52 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19611990 | 0.94 | CRBN (0.66) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL13716786 | 0.91 | CRBN (0.73) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1962104 | 0.90 | CRBN (0.84) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1962430 | 0.90 | CRBN (0.69) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1961945 | 0.90 | CRBN (0.64) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL2383146 | 0.90 | CRBN (0.72) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1964643 | 0.89 | CRBN (0.68) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL30484171 | 0.89 | CRBN (0.70) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL2383167 | 0.89 | CRBN (0.70) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1964603 | 0.89 | CRBN (0.70) | CRBNIKZF1CSNK1A1DDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240050428-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | CULLGEN (SHANGHAI), INC. (CN) | 2024-02-15 | — | — | US | disclosed |
| US-11345712-B2 | Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications | BIOTHERYX, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| WO-2020242960-A1 | COMPOUNDS TARGETING PROTEINS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2020-12-03 | — | — | WO | disclosed |
| US-20200369679-A1 | PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2020-11-26 | — | — | US | disclosed |
| EP-1919892-B1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORP (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8481568-B2 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION (US) | 2013-07-09 | — | — | US | disclosed |
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SEPRACOR INC. | 2011-06-16 | — | — | US | disclosed |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240050428-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | GSPT1, GGT1, VHL | CRBN 1484/4885IKZF1 4395/4885CSNK1A1 2528/4885 |
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SI, CYP3A5, CYP2D6 | CRBN 2589/4885IKZF1 658/4885CSNK1A1 137/4885 |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | SI, CYP3A5, CYP2D6 | CRBN 2589/4885IKZF1 658/4885CSNK1A1 137/4885 |
| US-11345712-B2 | Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications | HSP90B1, EIF4EBP1, SERPINA6 | CRBN 358/4885IKZF1 2328/4885CSNK1A1 520/4885 |
| US-20200369679-A1 | PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | HSP90B1, EIF4EBP1, SERPINA6 | CRBN 358/4885IKZF1 2328/4885CSNK1A1 520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.