Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.64 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.64 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.53 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | IL1B | P01584 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 8/20 | 0.49 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1963474 | 0.90 | CRBN (0.74) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL12554031 | 0.89 | CRBN (0.66) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| Hydrochloric Acid SCHEMBL1964328 | 0.88 | CRBN (0.65) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1962641 | 0.88 | CRBN (0.69) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1962434 | 0.88 | CRBN (0.58) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL21062843 | 0.88 | BRD4 (0.58) | CRBNIKZF1DDB1IKZF3BRD4 | |
| Hydrochloric Acid SCHEMBL1963612 | 0.87 | CRBN (0.68) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1962924 | 0.87 | CRBN (0.68) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL1964603 | 0.87 | CRBN (0.70) | CRBNIKZF1CSNK1A1DDB1IKZF3 | |
| SCHEMBL12587761 | 0.87 | CRBN (0.57) | CRBNIKZF1CSNK1A1DDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SEPRACOR INC. | 2011-06-16 | — | — | US | claimed |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION | 2007-03-01 | — | — | US | claimed |
| US-20140314752-A1 | METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY | SIGNAL PHARMACEUTICALS, LLC (US) | 2014-10-23 | — | — | US | disclosed |
| US-8481568-B2 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION (US) | 2013-07-09 | — | — | US | disclosed |
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SEPRACOR INC. | 2011-06-16 | — | — | US | disclosed |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | CELGENE CORPORATION | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140314752-A1 | METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY | MTOR, ULK1, RICTOR | CRBN 869/4885IKZF1 238/4885CSNK1A1 728/4885 |
| US-20110144158-A1 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | SI, CYP3A5, CYP2D6 | CRBN 2589/4885IKZF1 658/4885CSNK1A1 137/4885 |
| US-20070049618-A1 | Isoindole-imide compounds and compositions comprising and methods of using the same | SI, CYP3A5, CYP2D6 | CRBN 2589/4885IKZF1 658/4885CSNK1A1 137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.