Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17459786 | 0.77 | HTR6 (0.37) | HTR6SMN1; SMN2TLR8ALDH3A1LMNA | |
| SCHEMBL3634978 | 0.76 | SMN1; SMN2 (0.66) | SMN1; SMN2ALDH3A1ALDH1A1LMNAPKM | |
| SCHEMBL5144295 | 0.73 | TLR8 (0.44) | TLR8ALDH1A1AURKACYP1A2CYP3A4 | |
| SCHEMBL288963 | 0.72 | CACNA1H (0.33) | — | |
| SCHEMBL353025 | 0.71 | CYP1A2 (0.59) | SMN1; SMN2TLR8ALDH1A1AURKALMNA | |
| Formamide SCHEMBL28367514 | 0.70 | CYP1A2 (0.51) | TLR8ALDH1A1AURKALMNACYP1A2 | |
| SCHEMBL15112010 | 0.70 | KMT2A (0.40) | TLR8ALDH1A1AURKACYP1A2CYP3A4 | |
| SCHEMBL14304355 | 0.69 | TLR8 (0.41) | TLR8ALDH1A1AURKACYP1A2CYP3A4 | |
| SCHEMBL5144279 | 0.69 | DAO (0.41) | TLR8ALDH1A1AURKACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL28791312 | 0.69 | KMT2A (0.39) | TLR8ALDH1A1AURKACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854098-B | Benzimidazole derivatives as EP4 antagonists | 拜耳医药股份公司 | 2018-01-09 | — | — | CN | disclosed |
| US-9708311-B2 | Benzimidazole derivatives as EP4 antagonists | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-07-18 | — | — | US | disclosed |
| US-20160214977-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS | BAYER ANIMAL HEALTH GMBH (DE) | 2016-07-28 | — | — | US | disclosed |
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214977-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS | PTGER4, PTGER1, PTGER2 | HTR6 397/4885SMN1; SMN2 3924/4885TLR8 2348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.