Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 11/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.77 |
| ▸ | RAB9A | P51151 | 11/20 | 0.77 |
| ▸ | NPC1 | O15118 | 11/20 | 0.77 |
| ▸ | PKM | P14618 | 10/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.72 |
| ▸ | GRM5 | P41594 | 5/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | MITF | O75030 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5959953 | 0.87 | PKM (1.00) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL5225945 | 0.86 | PKM (0.63) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL21296247 | 0.82 | GRM5 (0.66) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL8051467 | 0.81 | CA2 (0.64) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL5959913 | 0.81 | PKM (0.77) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| Dimethylamine SCHEMBL4192736 | 0.81 | PKM (0.88) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL4198081 | 0.81 | SMN1; SMN2 (0.68) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL4187023 | 0.81 | GRM5 (1.00) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL11710966 | 0.81 | CA2 (0.68) | TP53SMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL4186253 | 0.81 | SMN1; SMN2 (0.68) | TP53SMN1; SMN2RAB9ANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598208-B2 | Pyridine derivatives as S1P1/EDG1 receptor modulators | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-12-03 | — | — | US | disclosed |
| US-20110212998-A1 | PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
| EP-2195311-B1 | PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-03-23 | — | — | EP | disclosed |
| EP-2195311-A1 | PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009024905-A1 | PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212998-A1 | PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS | S1PR1, S1PR3, S1PR2 | TP53 3880/4885SMN1; SMN2 4024/4885RAB9A 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.