Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14249703 | 0.92 | FLT3 (0.51) | FLT3PIK3CAMTORPIK3R1HDAC1 | |
| SCHEMBL14249330 | 0.86 | FLT3 (0.42) | FLT3PIK3CAMTORPIK3R1HDAC1 | |
| SCHEMBL14248878 | 0.81 | YTHDC1 (0.52) | FLT3ATR | |
| SCHEMBL14249161 | 0.75 | PIK3CA (0.42) | PIK3CAMTORPIK3R1ATR | |
| SCHEMBL12910252 | 0.75 | FLT3 (0.56) | FLT3PIK3CAMTORHDAC1HDAC3 | |
| SCHEMBL14250350 | 0.75 | FLT3 (0.43) | FLT3PIK3CAMTORPIK3R1HDAC1 | |
| SCHEMBL14251147 | 0.74 | FLT3 (0.42) | FLT3 | |
| SCHEMBL14316114 | 0.74 | YTHDC1 (0.56) | FLT3PIK3CAMTORATR | |
| SCHEMBL14296923 | 0.73 | FLT3 (0.38) | FLT3PIK3CA | |
| SCHEMBL14325243 | 0.72 | FLT3 (0.44) | FLT3HDAC1ATRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012172043-A1 | PURINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS FOR PREVENTION OR TREATMENT OF BACTERIAL INFECTIONS | LABORATOIRE BIODIM (FR) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012172043-A1 | PURINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS FOR PREVENTION OR TREATMENT OF BACTERIAL INFECTIONS | LABORATOIRE BIODIM (FR) | 2012-12-20 | — | — | WO | disclosed |