Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 10/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14249567 | 0.91 | PIK3CA (0.46) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL14249549 | 0.82 | MAP3K11 (0.34) | PIK3CAPIK3R1PIK3CDPIK3CBATR | |
| Hydrochloric Acid SCHEMBL14249557 | 0.81 | PIK3CA (0.35) | PIK3CAPIK3R1PIK3CDPIK3CBATR | |
| SCHEMBL14316031 | 0.77 | CNR2 (0.50) | CNR2KDM5BTDO2ATRATRIP | |
| SCHEMBL8079836 | 0.77 | PIK3CA (0.59) | PIK3CAPIK3R1PIK3CDPIK3CBATR | |
| SCHEMBL8062292 | 0.77 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDPIK3CBMTOR | |
| SCHEMBL14249658 | 0.75 | FLT3 (0.49) | PIK3CAPIK3R1ATRMTOR | |
| SCHEMBL12537215 | 0.74 | ATR (0.49) | PIK3CAPIK3R1ATRATRIPMTOR | |
| SCHEMBL1568626 | 0.70 | PIK3CA (0.65) | PIK3CAMTOR | |
| SCHEMBL27784940 | 0.70 | ADORA3 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012172043-A1 | PURINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS FOR PREVENTION OR TREATMENT OF BACTERIAL INFECTIONS | LABORATOIRE BIODIM (FR) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012172043-A1 | PURINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS FOR PREVENTION OR TREATMENT OF BACTERIAL INFECTIONS | LABORATOIRE BIODIM (FR) | 2012-12-20 | — | — | WO | disclosed |