Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21437933 | 0.85 | PNMT (0.54) | PNMTRAB9ANPC1HTR2BHTR7 | |
| SCHEMBL11570811 | 0.83 | PNMT (0.58) | PNMTRAB9ANPC1HTR2BHTR7 | |
| SCHEMBL27813798 | 0.82 | PNMT (0.50) | PNMTRAB9ANPC1HTR2BHTR7 | |
| SCHEMBL225715 | 0.81 | PNMT (0.60) | PNMTRAB9ANPC1HTR2BHTR7 | |
| SCHEMBL1568269 | 0.81 | PNMT (0.60) | PNMTRAB9ANPC1HTR2BHTR7 | |
| SCHEMBL11204188 | 0.80 | PNMT (0.63) | PNMTRAB9ANPC1HTR2BHTR7 | |
| SCHEMBL21758216 | 0.80 | PNMT (0.58) | PNMTRAB9ANPC1HTR2BHTR7 | |
| SCHEMBL14975286 | 0.80 | PNMT (0.51) | PNMTRAB9ANPC1HTR2BHTR7 | |
| SCHEMBL28481867 | 0.78 | MGLL (0.50) | PNMTRAB9ANPC1 | |
| SCHEMBL31026685 | 0.78 | PNMT (0.55) | PNMTRAB9ANPC1HTR2BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2721034-A1 | TRICYCLIC ANTIBIOTICS | Basilea Pharmaceutica AG (CH) | 2014-04-23 | — | — | EP | disclosed |
| WO-2012171860-A1 | TRICYCLIC ANTIBIOTICS | BASILEA PHARMACEUTICA AG (CH) | 2012-12-20 | — | — | WO | disclosed |