Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.54 |
| ▸ | SRC | P12931 | 5/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14253998 | 0.87 | MTOR (0.52) | MAPK8PIK3CGCAMKK2GSK3BCDK2 | |
| SCHEMBL14253974 | 0.86 | MAPK8 (0.61) | MAPK8PIK3CGCAMKK2GSK3BMAPK10 | |
| SCHEMBL14253977 | 0.86 | SYK (0.57) | SYKZAP70MAPK8PIK3CGCAMKK2 | |
| SCHEMBL14253994 | 0.84 | PIK3CG (0.54) | SYKMAPK8PIK3CGCAMKK2GSK3B | |
| SCHEMBL14254035 | 0.84 | MAPK8 (0.48) | SYKMAPK8PIK3CGCAMKK2JAK2 | |
| SCHEMBL14254000 | 0.84 | IKBKB (0.62) | MAPK8PIK3CGCAMKK2GSK3BMAPK10 | |
| SCHEMBL14254278 | 0.83 | SRC (0.55) | SYKSRCZAP70PIK3CGGSK3B | |
| SCHEMBL14254452 | 0.83 | SYK (0.57) | SYKSRCZAP70PIK3CGGSK3B | |
| SCHEMBL14254085 | 0.83 | CAMKK2 (0.52) | SYKSRCZAP70MAPK8PIK3CG | |
| SCHEMBL14254007 | 0.81 | CAMK2D (0.65) | MAPK8PIK3CGCAMKK2GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |