Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425497 | 0.89 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAPTPTGER1KMT2A | |
| SCHEMBL12811648 | 0.89 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1PTGER1 | |
| SCHEMBL1425623 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL1425564 | 0.81 | KDM5A (0.39) | ALDH1A1HSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL12811838 | 0.78 | ALDH1A1 (0.40) | ALDH1A1KDM4EPTGER1KMT2AMEN1 | |
| SCHEMBL1426147 | 0.78 | MAPK1 (0.39) | ALDH1A1KDM4EHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL1426475 | 0.76 | SMN1; SMN2 (0.40) | ALDH1A1HSD17B10HSP90AA1HSP90AB1MAPT | |
| SCHEMBL3304147 | 0.76 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSP90AA1HSP90AB1MAPT | |
| SCHEMBL1425991 | 0.74 | ALDH1A1 (0.42) | ALDH1A1MAPTHTTMAPK1KMT2A | |
| SCHEMBL1425480 | 0.74 | KDM4E (0.38) | ALDH1A1KDM4EHSP90AA1HSP90AB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118111-B1 | 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER | PFIZER (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | HSP90AB2P, HSP90AB1, HSP90AA1 | ALDH1A1 771/4885KDM4E 3595/4885HSD17B10 2668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.