Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | IDE | P14735 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12811844 | 0.90 | KDM4C (0.44) | KDM5AKDM4CKDM5BHSP90AA1HSP90AB1 | |
| SCHEMBL1425451 | 0.87 | ALDH1A1 (0.40) | HSP90AA1HSP90AB1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL1425497 | 0.84 | ALDH1A1 (0.40) | SMN1; SMN2TSHRALDH1A1PTGDR2 | |
| SCHEMBL1425516 | 0.81 | ALDH1A1 (0.41) | HSP90AA1HSP90AB1ALDH1A1HSD17B10 | |
| SCHEMBL1426475 | 0.79 | SMN1; SMN2 (0.40) | HSP90AA1HSP90AB1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL1425991 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2TSHRALDH1A1GAA | |
| SCHEMBL3304147 | 0.77 | ALDH1A1 (0.46) | HSP90AA1HSP90AB1ALDH1A1PTGDR2 | |
| SCHEMBL14134799 | 0.77 | HSP90AA1 (0.36) | KDM5AKDM5BHSP90AA1HSP90AB1 | |
| SCHEMBL1425421 | 0.76 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1 | |
| SCHEMBL13394107 | 0.75 | MAPT (0.36) | SMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118111-B1 | 2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER | PFIZER (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | PFIZER INC. | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093696-A1 | 2-AMINO PYRIMIDINE COMPOUNDS | HSP90AB2P, HSP90AB1, HSP90AA1 | KDM5A 3077/4885KDM4C 4111/4885KDM5B 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.