Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14255189 | 0.86 | KDM4E (0.53) | KDM4EMEN1KMT2AALDH1A1MAP2K1 | |
| SCHEMBL14255508 | 0.82 | ABL1 (0.49) | CHEK1KDM4ENR4A2PLA2G2AABL1 | |
| SCHEMBL14255509 | 0.81 | CHEK1 (0.47) | CHEK1KDM4ENR4A2PLA2G2AMEN1 | |
| SCHEMBL8878118 | 0.80 | MEN1 (0.46) | NR4A2MEN1KMT2AALDH1A1SLC40A1 | |
| SCHEMBL14255187 | 0.79 | KDM4E (0.57) | KDM4EMEN1KMT2AALDH1A1MAP2K1 | |
| SCHEMBL14255504 | 0.78 | CHEK1 (0.44) | CHEK1NR4A2PLA2G2AMEN1KMT2A | |
| SCHEMBL24338474 | 0.77 | KDM4E (0.50) | KDM4EMEN1KMT2ARXFP1KDR | |
| SCHEMBL13789515 | 0.76 | ALDH1A1 (0.44) | KDM4ENR4A2MEN1KMT2AKDR | |
| SCHEMBL13515356 | 0.74 | KDM4E (0.47) | KDM4EMEN1KMT2AABL1ALDH1A1 | |
| SCHEMBL6182503 | 0.72 | NR4A2 (0.50) | KDM4ENR4A2MEN1KMT2AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |