Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14255189 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1HPGDNPSR1PSMD14 | |
| SCHEMBL9945608 | 0.85 | KDM4E (0.57) | KDM4EALDH1A1HPGDNPSR1PSMD14 | |
| SCHEMBL14255197 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1HPGDNPSR1PSMD14 | |
| SCHEMBL14255204 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1HPGDNPSR1PSMD14 | |
| SCHEMBL14255505 | 0.79 | CHEK1 (0.49) | KDM4EALDH1A1MAP2K1SLC40A1MEN1 | |
| SCHEMBL14255190 | 0.78 | MEN1 (0.45) | KDM4EALDH1A1HPGDNPSR1MAPT | |
| SCHEMBL1539120 | 0.76 | ALDH1A1 (0.66) | KDM4EALDH1A1HPGDNPSR1MAPT | |
| SCHEMBL23212200 | 0.76 | KDM4E (0.57) | KDM4EALDH1A1HPGDNPSR1PSMD14 | |
| SCHEMBL23233761 | 0.74 | KDM4E (0.70) | KDM4EALDH1A1PSMD14MAP2K1SLC40A1 | |
| SCHEMBL14255198 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1HPGDNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| US-7342016-B2 | Farnesyl protein transferase inhibitors as antitumor agents | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1313725-B1 | TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS | SCHERING CORP (US) | 2007-04-11 | — | — | EP | disclosed |