Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | FABP7 | O15540 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14256064 | 1.00 | REN (0.47) | RENALDH1A1MAPTPKMFABP7 | |
| SCHEMBL14256066 | 0.82 | MAPT (0.46) | RENMAPTPKM | |
| SCHEMBL14256187 | 0.82 | MAPT (0.46) | RENMAPTPKM | |
| SCHEMBL14256204 | 0.80 | MAPT (0.44) | RENMAPTPKM | |
| SCHEMBL14256069 | 0.79 | MAPT (0.46) | RENMAPTPKMFABP7FABP3 | |
| SCHEMBL14256068 | 0.79 | KDM1A (0.44) | RENMAPTPKM | |
| SCHEMBL14256230 | 0.79 | MAPT (0.50) | RENMAPTPKMFABP7FABP3 | |
| SCHEMBL14256183 | 0.78 | REN (0.53) | RENALDH1A1MAPTPKM | |
| SCHEMBL14256192 | 0.78 | REN (0.51) | REN | |
| SCHEMBL14256163 | 0.78 | REN (0.53) | RENMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |