Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.51 |
| ▸ | EED | O75530 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14256183 | 0.88 | REN (0.53) | REN | |
| SCHEMBL14256066 | 0.87 | MAPT (0.46) | RENKDM1A | |
| SCHEMBL14256187 | 0.87 | MAPT (0.46) | RENKDM1A | |
| SCHEMBL14256161 | 0.82 | REN (0.60) | RENMAOBHTR2C | |
| SCHEMBL14256227 | 0.80 | REN (0.51) | REN | |
| SCHEMBL14256155 | 0.78 | REN (0.47) | REN | |
| SCHEMBL14256064 | 0.78 | REN (0.47) | REN | |
| SCHEMBL14256204 | 0.78 | MAPT (0.44) | RENKDM1A | |
| SCHEMBL14256230 | 0.74 | MAPT (0.50) | RENKDM1AMAOAMAOB | |
| SCHEMBL14256225 | 0.73 | REN (0.45) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |