Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.72 |
| ▸ | CNR2 | P34972 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 5/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14258615 | 0.87 | CNR1 (0.70) | CNR1CNR2KMT2APOLBHSD17B10 | |
| SCHEMBL14258623 | 0.87 | CNR1 (0.83) | CNR1CNR2POLBMAPTL3MBTL1 | |
| SCHEMBL3305857 | 0.84 | CNR1 (1.00) | CNR1CNR2PARP1 | |
| SCHEMBL14258609 | 0.84 | CNR1 (0.81) | CNR1CNR2KMT2AALDH1A1PARP1 | |
| SCHEMBL14258913 | 0.83 | CNR1 (0.70) | CNR1CNR2POLBMAPTL3MBTL1 | |
| SCHEMBL4781853 | 0.83 | CNR1 (0.70) | CNR1CNR2POLBMAPTL3MBTL1 | |
| SCHEMBL14259953 | 0.81 | CNR1 (0.61) | CNR1CNR2KMT2APOLBHSD17B10 | |
| SCHEMBL3720419 | 0.79 | POLB (0.74) | KMT2APOLBHSD17B10MAPTTDP1 | |
| SCHEMBL13329695 | 0.78 | BAZ2B (0.61) | CNR1CNR2KMT2APOLBMAPT | |
| SCHEMBL3724918 | 0.78 | L3MBTL1 (0.62) | CNR1CNR2KMT2AMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008036021-A1 | TETRAHYDRO-LH-PYRIDO [3,4 -B] INDOLE DERIVATIVES AS CBL RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008036022-A1 | TETRAHYDRO-LH-PYRIDO[3,4-B] INDOLE DERIVATIVES AS CB1 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2008-03-27 | — | — | WO | disclosed |