Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TARS1 | P26639 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5010329 | 0.88 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL3321297 | 0.87 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL14259221 | 0.87 | SMN1; SMN2 (0.39) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL3319448 | 0.87 | AAK1 (0.40) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL13689445 | 0.86 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL13335744 | 0.86 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL13335769 | 0.85 | SHMT1 (0.40) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL5052311 | 0.84 | ALDH1A1 (0.43) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL13335746 | 0.84 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2POLBKDM4E | |
| SCHEMBL13335687 | 0.84 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008025509-A1 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-06 | — | — | WO | disclosed |