Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12893198 | 0.86 | LMNA (0.54) | LMNAMAOACASP1GAAL3MBTL1 | |
| SCHEMBL12893200 | 0.86 | LMNA (0.54) | LMNAMAOACASP1GAAL3MBTL1 | |
| SCHEMBL28232465 | 0.85 | LMNA (0.54) | LMNAMAOACASP1GAAL3MBTL1 | |
| SCHEMBL12893214 | 0.80 | SLC6A4 (0.50) | LMNAL3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL17523062 | 0.77 | ESR1 (0.59) | LMNACASP1GAAL3MBTL1MEN1 | |
| SCHEMBL19268516 | 0.77 | ESR1 (0.59) | LMNACASP1GAAL3MBTL1MEN1 | |
| SCHEMBL25620272 | 0.77 | ESR1 (0.59) | LMNACASP1GAAL3MBTL1MEN1 | |
| SCHEMBL29813419 | 0.76 | LMNA (0.49) | LMNAMAOACASP1GAAL3MBTL1 | |
| SCHEMBL8065672 | 0.76 | LMNA (0.49) | LMNAMAOACASP1GAAL3MBTL1 | |
| SCHEMBL19863729 | 0.75 | ESR1 (0.58) | LMNACASP1GAAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033894-A2 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2008-03-20 | — | — | WO | disclosed |
| WO-2007056500-A2 | COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS | ACADIA PHARMACEUTICALS INC. (US) | 2007-05-18 | — | — | WO | disclosed |