Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | UBE2M | P61081 | 4/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.44 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980678 | 0.92 | UBE2M (0.54) | DRD4MCHR1KCNH2UBE2MDCUN1D1 | |
| SCHEMBL14263134 | 0.85 | DRD4 (0.55) | DRD4MCHR1EPHX1HPGDMEN1 | |
| SCHEMBL14263087 | 0.85 | MCHR1 (0.52) | DRD4MCHR1KCNH2EPHX1HPGD | |
| SCHEMBL4981612 | 0.84 | DRD4 (0.57) | DRD4MCHR1EPHX1HPGDUBE2M | |
| SCHEMBL4981951 | 0.84 | MCHR1 (0.56) | DRD4MCHR1KCNH2EPHX1HPGD | |
| SCHEMBL4982704 | 0.83 | CARM1 (0.55) | DRD4MCHR1EPHX1SSTR4EPHX2 | |
| SCHEMBL14263126 | 0.82 | SSTR1 (0.57) | DRD4MCHR1EPHX1HPGDUBE2M | |
| SCHEMBL14263114 | 0.81 | DRD4 (0.73) | DRD4MCHR1EPHX1HPGDMEN1 | |
| SCHEMBL4979582 | 0.80 | SLC6A5 (0.59) | DRD4MCHR1KCNH2EPHX1HPGD | |
| SCHEMBL4977767 | 0.80 | MCHR1 (0.65) | DRD4MCHR1SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064706-A1 | Piperidine Derivatives as Histamine H3 Receptor Ligands | HRH3, HRH1, HRH4 | DRD4 102/4885MCHR1 132/4885KCNH2 434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.