Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | THRB | P10828 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | CETP | P11597 | 11/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15745638 | 0.88 | NPC1 (0.66) | MAPTTHRBSMN1; SMN2RXFP1NPC1 | |
| SCHEMBL11446660 | 0.86 | NPC1 (0.64) | MAPTTHRBSMN1; SMN2RXFP1NPC1 | |
| SCHEMBL9681997 | 0.81 | NPC1 (0.71) | MAPTTHRBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14266179 | 0.81 | ALDH1A1 (0.59) | MAPTTHRBSMN1; SMN2RXFP1NPC1 | |
| SCHEMBL14666773 | 0.79 | NPC1 (0.57) | MAPTTHRBSMN1; SMN2RXFP1NPC1 | |
| SCHEMBL19440714 | 0.79 | NPC1 (0.57) | MAPTTHRBSMN1; SMN2RXFP1NPC1 | |
| SCHEMBL11167498 | 0.78 | NPC1 (0.56) | MAPTTHRBSMN1; SMN2RXFP1NPC1 | |
| SCHEMBL11160763 | 0.78 | NPC1 (0.56) | MAPTTHRBSMN1; SMN2RXFP1NPC1 | |
| SCHEMBL29460440 | 0.78 | ALDH1A1 (0.78) | MAPTTHRBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4464248 | 0.78 | HDAC6 (0.56) | MAPTTHRBSMN1; SMN2RXFP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345068-B2 | Aromatic amino acid derivatives and medicinal compositions | Endou, Hitoshi (JP) | 2008-03-18 | — | — | US | disclosed |
| US-7345068-B2 | Aromatic amino acid derivatives and medicinal compositions | Endou, Hitoshi (JP) | 2008-03-18 | — | — | US | disclosed |