Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1427063 | 0.83 | MET (0.53) | METALDH1A1 | |
| SCHEMBL1427146 | 0.83 | MET (0.49) | METKDRALDH1A1 | |
| SCHEMBL1427084 | 0.82 | MET (0.52) | METALDH1A1 | |
| SCHEMBL1427643 | 0.80 | MET (0.51) | METKDRAURKB | |
| SCHEMBL1464337 | 0.80 | MET (0.49) | METTSHRALDH1A1 | |
| SCHEMBL12922931 | 0.79 | MET (1.00) | METKDRALDH1A1EPHX2 | |
| SCHEMBL12747571 | 0.78 | MET (0.48) | METKDRALDH1A1 | |
| SCHEMBL12747569 | 0.77 | MET (0.44) | METTP53 | |
| SCHEMBL982217 | 0.76 | MET (0.67) | METTSHRKDM4EALDH1A1EPHX2 | |
| SCHEMBL1427614 | 0.75 | MET (0.54) | METTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300434-B1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2014-07-23 | — | — | EP | claimed |
| US-8404685-B2 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-03-26 | — | — | US | claimed |
| US-20110071153-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-24 | — | — | US | claimed |
| EP-2300434-B1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2014-07-23 | — | — | EP | disclosed |
| EP-2300434-B1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2014-07-23 | — | — | EP | disclosed |
| US-8404685-B2 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-03-26 | — | — | US | disclosed |
| US-8404685-B2 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-03-26 | — | — | US | disclosed |
| US-8404685-B2 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-03-26 | — | — | US | disclosed |
| EP-2300434-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2011-03-30 | — | — | EP | disclosed |
| US-20110071153-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-24 | — | — | US | disclosed |
| US-20110071153-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-24 | — | — | US | disclosed |
| US-20110071153-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-24 | — | — | US | disclosed |
| WO-2009143945-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH, (DE) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009143945-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH, (DE) | 2009-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071153-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | RET, FLT3, TYRO3 | MET 4/4885TSHR 546/4885KDM4E 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.