Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.35 |
| ▸ | FNTA | P49354 | 7/20 | 0.34 |
| ▸ | FNTB | P49356 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1427063 | 0.96 | MET (0.53) | METORAI1HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL1427084 | 0.88 | MET (0.52) | METORAI1HCRTR1HCRTR2FNTA | |
| SCHEMBL12747571 | 0.83 | MET (0.48) | METORAI1HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL1427146 | 0.82 | MET (0.49) | METORAI1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1427192 | 0.80 | MET (0.65) | METALDH1A1TSHR | |
| SCHEMBL12827536 | 0.79 | MET (0.45) | METORAI1HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL1427643 | 0.79 | MET (0.51) | METORAI1HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL1427614 | 0.79 | MET (0.54) | METORAI1HCRTR1HCRTR2LMNA | |
| SCHEMBL983930 | 0.78 | MET (0.58) | METORAI1ALDH1A1LMNAPKM | |
| SCHEMBL13580043 | 0.78 | MET (0.58) | METORAI1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071153-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GESELLSCHAFT (DE) | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071153-A1 | DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS | RET, FLT3, TYRO3 | MET 4/4885ORAI1 4554/4885HCRTR1 2682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.