Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | GPX4 | P36969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13688795 | 0.89 | BRAF (0.37) | BRAFMAPK14GSK3APTK2 | |
| SCHEMBL13688769 | 0.89 | MAPK14 (0.40) | BRAFMAPK14MAPTPTK2GPX4 | |
| SCHEMBL13688785 | 0.88 | MAPK14 (0.39) | BRAFMAPK14GSK3APTK2 | |
| SCHEMBL14276192 | 0.87 | MAPK14 (0.45) | MAPK14GSK3APTK2 | |
| SCHEMBL13688789 | 0.87 | GSK3A (0.43) | BRAFMAPK14GSK3A | |
| SCHEMBL5682608 | 0.87 | MAPK14 (0.57) | BRAFMAPK14GSK3A | |
| SCHEMBL14276165 | 0.86 | MAPK14 (0.44) | MAPK14GSK3A | |
| SCHEMBL14276136 | 0.85 | GSK3A (0.47) | MAPK14KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL5685205 | 0.85 | MAPK14 (0.38) | BRAFMAPK14ALDH1A1GSK3APTK2 | |
| SCHEMBL14276166 | 0.85 | MAPK14 (0.42) | BRAFMAPK14GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631567-A2 | HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005016918-A2 | HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | claimed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |