Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5104947 | 0.87 | HSD11B1 (0.38) | HSD11B1HSD17B1GAARAB9A | |
| Fluoroacetate SCHEMBL6357897 | 0.87 | HSD11B1 (0.35) | HSD11B1HSD17B1GAARAB9AMEN1 | |
| SCHEMBL5104767 | 0.83 | HSD11B1 (0.46) | HSD11B1HSD17B1GAARAB9AMEN1 | |
| SCHEMBL5098423 | 0.81 | HSD11B1 (0.40) | HSD11B1HSD17B1GAARAB9A | |
| SCHEMBL2667916 | 0.81 | HSD11B1 (0.41) | HSD11B1HSD17B1GAARAB9A | |
| SCHEMBL5104628 | 0.81 | HSD11B1 (0.41) | HSD11B1HSD17B1GAARAB9A | |
| SCHEMBL2383169 | 0.73 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL14277222 | 0.73 | HSD11B1 (0.41) | HSD11B1HSD17B1GAARAB9AMEN1 | |
| SCHEMBL14277223 | 0.73 | HSD11B1 (0.38) | HSD11B1HSD17B1GAARAB9AMEN1 | |
| SCHEMBL5098048 | 0.73 | HSD11B1 (0.38) | HSD11B1HSD17B1GAARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329683-B2 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329683-B2 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1474139-B1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES, OBESITY AND DYSLIPIDEMIA | MERCK & CO INC (US) | 2007-11-21 | — | — | EP | disclosed |