Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382882 | 0.84 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL12303174 | 0.74 | HSD11B1 (0.53) | HSD11B1HSD11B2 | |
| SCHEMBL14277239 | 0.73 | HSD11B1 (0.40) | HSD11B1 | |
| SCHEMBL13211429 | 0.70 | — | — | |
| SCHEMBL13211412 | 0.68 | HSD11B1 (0.43) | HSD11B1HSD11B2 | |
| SCHEMBL13784375 | 0.66 | HSD11B1 (0.52) | HSD11B1HSD11B2 | |
| Fluoroacetate SCHEMBL6357897 | 0.66 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL13784359 | 0.62 | HSD11B1 (0.74) | HSD11B1HSD11B2 | |
| SCHEMBL2381963 | 0.62 | HSD11B1 (1.00) | HSD11B1HSD11B2 | |
| SCHEMBL10783825 | 0.62 | TSHR (0.41) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026264-B2 | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 | MERCK SHARP AND DOHME CORP. (US) | 2011-09-27 | — | — | US | disclosed |
| US-8026264-B2 | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 | MERCK SHARP AND DOHME CORP. (US) | 2011-09-27 | — | — | US | disclosed |
| US-8026264-B2 | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 | MERCK SHARP AND DOHME CORP. (US) | 2011-09-27 | — | — | US | disclosed |
| EP-1638947-B1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-1638947-B1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-08-04 | — | — | EP | disclosed |
| US-20060258695-A1 | Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2006-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258695-A1 | Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885HSD11B2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.