Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800641 | 0.71 | CYP3A4 (0.39) | HTTKDM4EGAATSHR | |
| SCHEMBL5582659 | 0.71 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL8627801 | 0.69 | POLB (0.41) | POLBSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL1558723 | 0.67 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL11117869 | 0.64 | POLB (0.47) | POLBSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL117382 | 0.64 | CYP3A4 (0.55) | ALDH1A1HSD17B10TDP1KDM4EMAPK1 | |
| SCHEMBL29401947 | 0.64 | CYP3A4 (0.55) | ALDH1A1HSD17B10TDP1KDM4EMAPK1 | |
| SCHEMBL1461902 | 0.63 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| SCHEMBL2816131 | 0.63 | CYP2A6 (0.47) | POLBSMN1; SMN2ALDH1A1HTTHSD17B10 | |
| Hydrochloric Acid SCHEMBL6446846 | 0.63 | CYP3A4 (0.53) | ALDH1A1HSD17B10TDP1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300466-A1 | IMIDAZOPYRIDINE AND IMIDAZOPYRAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2009155388-A1 | IMIDAZOPYRIDINE AND IMIDAZOPYRAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-23 | — | — | WO | disclosed |