SCHEMBL14280532

SCHEMBL14280532

Cc1ccc(Oc2c(C(C)(C)C)cc(-c3ccc(N4C(=O)C5(C(=O)N(C)C5=O)C4=O)cc3)cc2C(C)(C)C)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 3/20 0.35
NPC1 O15118 1/20 0.32
NPBWR1 P48145 5/20 0.32
MCHR1 Q99705 4/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
F2 P00734 1/20 0.31
CTSG P08311 1/20 0.31
CMA1 P23946 1/20 0.31
CTRC Q99895 1/20 0.31
PTGS1 P23219 1/20 0.31
PTGS2 P35354 1/20 0.31
MAPK14 Q16539 1/20 0.30
GRIA2 P42262 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14280535 0.85 MAPT (0.36) ELANEMEN1KMT2ASMN1; SMN2KDM4E
SCHEMBL13923515 0.80 ELANE (0.47) ELANEMEN1KMT2AALDH1A1MAPT
SCHEMBL14280534 0.79 NPSR1 (0.41) MEN1KMT2ANPSR1SMN1; SMN2ALDH1A1
SCHEMBL15829556 0.73 ELANE (0.41) ELANENPC1MEN1KMT2ASMN1; SMN2
SCHEMBL13226476 0.68 ELANE (0.64) ELANENPC1SMN1; SMN2ALDH1A1MAPT
SCHEMBL28573249 0.67 TEAD4 (0.45) NPC1MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4857603 0.66 ALDH1A1 (0.50) NPC1MEN1KMT2ASMN1; SMN2KDM4E
SCHEMBL28581599 0.65 ALDH1A1 (0.46) NPC1MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL14510997 0.64 ELANE (0.40) ELANEMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL13855427 0.64 TP53 (0.46) ELANEMEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7317110-B2 Low dielectric constant organo-soluble polyimides HOME SUN INDUSTRIAL CO., LTD. (TW) 2008-01-08 US disclosed