SCHEMBL14280535

SCHEMBL14280535

CC(C)(C)c1cc(-c2ccc(N3C(=O)CC3=O)cc2)cc(C(C)(C)C)c1Oc1ccc(N2C(=O)C3(C2=O)C(=O)N(c2ccc(-c4cc(C(C)(C)C)c(Oc5ccc(N6C(=O)CC6=O)cc5)c(C(C)(C)C)c4)cc2)C3=O)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
RAB9A P51151 1/20 0.36
POLB P06746 1/20 0.35
ALDH1A1 P00352 4/20 0.34
LMNA P02545 2/20 0.34
GLA P06280 1/20 0.32
ELANE P08246 1/20 0.32
GAA P10253 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
USP2 O75604 1/20 0.32
ALOX15 P16050 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
APP P05067 1/20 0.32
APAF1 O14727 1/20 0.31
KDM4E B2RXH2 1/20 0.30
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14280532 0.85 ELANE (0.35) MAPTMEN1KMT2AALDH1A1ELANE
SCHEMBL14280534 0.70 NPSR1 (0.41) MAPTMEN1KMT2APOLBALDH1A1
SCHEMBL4857603 0.69 ALDH1A1 (0.50) MAPTMEN1KMT2ARAB9APOLB
SCHEMBL4860415 0.66 HTT (0.49) MAPTMEN1KMT2ARAB9APOLB
SCHEMBL28581599 0.61 ALDH1A1 (0.46) MAPTMEN1KMT2ARAB9APOLB
SCHEMBL13923515 0.61 ELANE (0.47) MAPTMEN1KMT2APOLBALDH1A1
SCHEMBL31179999 0.60 MGLL (0.54) MEN1KMT2AALDH1A1LMNATDP1
SCHEMBL32668241 0.59 POLB (0.70) MAPTKMT2APOLBALDH1A1LMNA
SCHEMBL23952826 0.59 POLB (0.59) KMT2APOLBALDH1A1LMNAGLA
SCHEMBL31180052 0.58 MGLL (0.56) MEN1KMT2AALDH1A1LMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7317110-B2 Low dielectric constant organo-soluble polyimides HOME SUN INDUSTRIAL CO., LTD. (TW) 2008-01-08 US disclosed