Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 6/20 | 0.43 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.43 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.43 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.43 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.43 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.43 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280676 | 0.88 | OPRM1 (0.52) | OPRM1OPRK1OPRL1HRH2HTR2A | |
| SCHEMBL14280675 | 0.77 | OPRL1 (0.55) | OPRM1OPRK1OPRL1HRH2HTR2A | |
| SCHEMBL14280679 | 0.76 | CNR1 (0.48) | OPRM1OPRK1OPRL1HRH2HTR2A | |
| SCHEMBL4882103 | 0.74 | HTR6 (0.50) | OPRM1OPRK1OPRL1CNR1CNR2 | |
| SCHEMBL4873314 | 0.72 | OPRM1 (0.45) | OPRM1OPRK1OPRL1HRH2CACNB4 | |
| SCHEMBL14280681 | 0.72 | OPRM1 (0.79) | OPRM1OPRK1OPRL1HTR2AMEN1 | |
| SCHEMBL14280683 | 0.69 | OPRM1 (0.57) | OPRM1OPRK1OPRL1MEN1KMT2A | |
| SCHEMBL5420593 | 0.69 | CACNB4 (0.53) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| Hydrochloric Acid SCHEMBL5419186 | 0.68 | CACNB4 (0.52) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL14280689 | 0.68 | OPRM1 (0.64) | OPRM1OPRK1OPRL1HRH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | OGFRL1, OPRL1, ORMDL3 | OPRM1 11/4885OPRK1 5/4885OPRL1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.