Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 16/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 14/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | PER2 | O15055 | 1/20 | 0.36 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.36 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280691 | 0.89 | OPRL1 (0.81) | OPRL1OPRM1OPRK1OPRD1HRH2 | |
| SCHEMBL14280692 | 0.89 | OPRL1 (0.80) | OPRL1OPRM1OPRK1OPRD1HRH2 | |
| SCHEMBL4881230 | 0.81 | OPRL1 (0.67) | OPRL1OPRM1OPRK1OPRD1HRH2 | |
| SCHEMBL4881232 | 0.81 | OPRL1 (0.67) | OPRL1OPRM1OPRK1OPRD1HRH2 | |
| SCHEMBL14306729 | 0.80 | OPRL1 (0.66) | OPRL1OPRM1OPRK1OPRD1HRH2 | |
| SCHEMBL14280689 | 0.74 | OPRM1 (0.64) | OPRL1OPRM1OPRK1HRH2DRD2 | |
| SCHEMBL14280690 | 0.71 | OPRL1 (1.00) | OPRL1OPRM1OPRK1OPRD1DRD2 | |
| SCHEMBL14280675 | 0.71 | OPRL1 (0.55) | OPRL1OPRM1OPRK1OPRD1HRH2 | |
| SCHEMBL14280673 | 0.70 | OPRL1 (1.00) | OPRL1OPRM1OPRK1OPRD1SLC6A4 | |
| SCHEMBL5138359 | 0.69 | OPRL1 (0.64) | OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015214-A1 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | OGFRL1, OPRL1, ORMDL3 | OPRL1 2/4885OPRM1 11/4885OPRK1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.