Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4871637 | 0.82 | OPRL1 (0.55) | OPRL1OPRM1OPRK1 | |
| SCHEMBL4871631 | 0.82 | OPRL1 (0.55) | OPRL1OPRM1OPRK1 | |
| SCHEMBL14305540 | 0.78 | OPRL1 (1.00) | OPRL1OPRM1OPRK1 | |
| SCHEMBL14305526 | 0.78 | OPRL1 (0.83) | OPRL1OPRM1 | |
| SCHEMBL4877078 | 0.76 | OPRL1 (0.68) | OPRL1OPRM1OPRK1 | |
| SCHEMBL14280708 | 0.70 | OPRL1 (0.64) | OPRL1OPRM1OPRK1 | |
| SCHEMBL14305528 | 0.69 | OPRL1 (0.72) | OPRL1OPRM1OPRK1 | |
| SCHEMBL14280693 | 0.69 | OPRL1 (1.00) | OPRL1OPRM1OPRK1 | |
| SCHEMBL14530065 | 0.67 | OPRM1 (0.53) | OPRL1OPRM1OPRK1 | |
| SCHEMBL4871619 | 0.63 | OPRL1 (1.00) | OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945213-A2 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007050381-A2 | 3-PIPERIDIN-4-YL-INDOLE ORL-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-05-03 | — | — | WO | disclosed |