SCHEMBL14281167

SCHEMBL14281167

O=S1(=O)c2ccccc2N(CN2c3ccccc3S(=O)(=O)c3ccccc32)c2ccccc21

nearest known ligand 0.66

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 2/20 0.66
TP53 P04637 3/20 0.59
LMNA P02545 6/20 0.58
MAPT P10636 4/20 0.58
THRB P10828 1/20 0.58
POLB P06746 1/20 0.58
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
HDAC1 Q13547 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
HTR1A P08908 1/20 0.49
HTR2A P28223 1/20 0.49
HTR7 P34969 1/20 0.49
HTR6 P50406 1/20 0.49
GPR3 P46089 1/20 0.46
NOX1 Q9Y5S8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30433630 0.83 RXFP1 (0.61) RXFP1TP53LMNAMAPTTHRB
SCHEMBL4307189 0.83 RXFP1 (0.61) RXFP1TP53LMNAMAPTTHRB
SCHEMBL14281166 0.83 RXFP1 (0.61) RXFP1TP53LMNAMAPTTHRB
SCHEMBL12349334 0.75 RXFP1 (0.53) RXFP1TP53LMNAMAPTTHRB
SCHEMBL25058995 0.74 RXFP1 (0.52) RXFP1TP53LMNAMAPTTHRB
SCHEMBL2494216 0.74 MAOA (0.58) RXFP1TP53LMNAMAPTTHRB
SCHEMBL20218900 0.74 RXFP1 (0.52) RXFP1TP53LMNAMAPTTHRB
SCHEMBL10349326 0.74 CES1 (0.53) RXFP1TP53LMNAMAPTTHRB
SCHEMBL11182750 0.74 RXFP1 (0.51) RXFP1TP53LMNAMAPTTHRB
SCHEMBL32667803 0.74 CES1 (0.53) RXFP1TP53LMNAMAPTTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080018238-A1 Use Of Phenothiazine-S-Oxides And Phenothiazine -S,S-Dioxides In The Form Of Matrix Materials For Organic Light-Emitting Diodes BASF AKTIENGESELLSCHAFT (DE) 2008-01-24 US disclosed
US-20080018238-A1 Use Of Phenothiazine-S-Oxides And Phenothiazine -S,S-Dioxides In The Form Of Matrix Materials For Organic Light-Emitting Diodes BASF AKTIENGESELLSCHAFT (DE) 2008-01-24 US disclosed