Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 11/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | FSHR | P23945 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928354 | 0.88 | LHCGR (0.58) | LHCGRTSHRFSHRRAB9ANPC1 | |
| SCHEMBL5140326 | 0.87 | LHCGR (0.73) | LHCGRTSHRFSHRRAB9ANPC1 | |
| SCHEMBL4906981 | 0.87 | LHCGR (0.56) | LHCGRTSHRFSHRMYCWDR5 | |
| SCHEMBL4421168 | 0.87 | LHCGR (0.84) | LHCGRTSHRFSHRCHRM4BRAF | |
| SCHEMBL14285233 | 0.87 | LHCGR (0.56) | LHCGRTSHRFSHRRAB9ANPC1 | |
| SCHEMBL4315364 | 0.86 | LHCGR (1.00) | LHCGRTSHRFSHRCHRM4BRAF | |
| SCHEMBL4313210 | 0.85 | LHCGR (1.00) | LHCGRTSHRFSHRRAB9ANPC1 | |
| SCHEMBL5034024 | 0.85 | LHCGR (0.65) | LHCGRTSHRFSHRRAB9ANPC1 | |
| SCHEMBL4326072 | 0.85 | LHCGR (1.00) | LHCGRTSHRFSHRRAB9ANPC1 | |
| SCHEMBL5034065 | 0.84 | LHCGR (0.67) | LHCGRTSHRFSHRRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317006-B2 | Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity | N.V. ORGANON (NL) | 2008-01-08 | — | — | US | disclosed |
| US-7317006-B2 | Thieno[2,3-d]pyrimidines with combined LH and FSH agonistic activity | N.V. ORGANON (NL) | 2008-01-08 | — | — | US | disclosed |