Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.42 |
| ▸ | RXRB | P28702 | 4/20 | 0.42 |
| ▸ | RXRG | P48443 | 4/20 | 0.42 |
| ▸ | CYP26B1 | Q9NR63 | 8/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.40 |
| ▸ | RARA | P10276 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | RARG | P13631 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286073 | 0.86 | RXRA (0.53) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL2238564 | 0.84 | RXRA (0.42) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL13318274 | 0.77 | RXRA (0.42) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL14286050 | 0.75 | RXRA (0.41) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL3176733 | 0.73 | RXRA (0.54) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL2090508 | 0.73 | ESR2 (0.42) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL2897524 | 0.70 | CYP26B1 (0.53) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL2090382 | 0.70 | ESR2 (0.40) | ESR1ESR2TP53 | |
| SCHEMBL694638 | 0.68 | RXRA (0.53) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL1616186 | 0.68 | RXRA (0.53) | RXRARXRBRXRGCYP26B1CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030618-A1 | BENZO-FUSED COMPOUNDS FOR USE IN TREATING METABOLIC DISORDERS | AMGEN INC. (US) | 2008-03-13 | — | — | WO | disclosed |