Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL267926 | 0.82 | NR1H3 (0.58) | NR1H3PTGS1PTPN1 | |
| SCHEMBL14286750 | 0.82 | NR1H3 (0.58) | NR1H3PTGS1PTPN1 | |
| SCHEMBL14286749 | 0.82 | NR1H3 (0.44) | NR1H3PTGS1PTPN1 | |
| SCHEMBL12450206 | 0.82 | NR1H3 (0.58) | NR1H3PTGS1PTPN1 | |
| SCHEMBL280434 | 0.82 | CYP19A1 (0.39) | NR1H3PTGS1PTPN1CYP19A1 | |
| SCHEMBL14112376 | 0.81 | NR1H3 (0.42) | NR1H3PTGS1PTPN1CYP19A1 | |
| SCHEMBL14112380 | 0.79 | PTGS1 (0.61) | NR1H3PTGS1PTPN1 | |
| SCHEMBL12704627 | 0.78 | PTGS1 (0.49) | NR1H3PTGS1PTPN1CYP19A1 | |
| SCHEMBL267197 | 0.77 | NR1H3 (0.39) | NR1H3PTGS1PTPN1CYP19A1 | |
| SCHEMBL6008324 | 0.77 | PTGS1 (0.48) | NR1H3PTGS1PTPN1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064753-A1 | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators | HENSLER, MARY | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064753-A1 | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators | IL1A, IL1B, TNF | NR1H3 3538/4885PTGS1 20/4885PTPN1 2008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.