Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.45 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14287690 | 0.90 | HRH3 (0.61) | HRH3 | |
| SCHEMBL14287695 | 0.85 | HRH3 (0.69) | HRH3 | |
| SCHEMBL14287692 | 0.83 | HRH3 (0.52) | HRH3HSP90B1TRAP1ACACB | |
| SCHEMBL5097358 | 0.83 | HRH3 (0.69) | HRH3KDM4EACACB | |
| SCHEMBL5100209 | 0.81 | HRH3 (1.00) | HRH3 | |
| SCHEMBL14287694 | 0.81 | HRH3 (0.49) | HRH3HSP90B1TRAP1ACACB | |
| Hydrochloric Acid SCHEMBL5093907 | 0.80 | HRH3 (0.98) | HRH3 | |
| SCHEMBL5100248 | 0.80 | HRH3 (0.61) | HRH3HSP90B1TRAP1 | |
| SCHEMBL5093660 | 0.80 | HRH3 (0.88) | HRH3 | |
| SCHEMBL14287697 | 0.79 | HRH3 (0.49) | HRH3SMN1; SMN2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |