Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.49 |
| ▸ | MOGAT2 | Q3SYC2 | 4/20 | 0.45 |
| ▸ | ACACB | O00763 | 4/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14287694 | 0.82 | HRH3 (0.49) | HRH3ACACBDRD2KCNH2PRMT5 | |
| SCHEMBL14287690 | 0.79 | HRH3 (0.61) | HRH3DRD2 | |
| SCHEMBL14287689 | 0.79 | HRH3 (0.68) | HRH3ACACBSMN1; SMN2 | |
| SCHEMBL14287695 | 0.76 | HRH3 (0.69) | HRH3 | |
| SCHEMBL6972852 | 0.75 | DRD2 (0.57) | DRD2KCNH2PRMT5WDR77LMNA | |
| SCHEMBL14287692 | 0.74 | HRH3 (0.52) | HRH3ACACB | |
| SCHEMBL27876255 | 0.73 | KCNA5 (0.63) | HRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3702304 | 0.72 | OPRM1 (0.83) | OPRM1OPRD1OPRK1 | |
| SCHEMBL23259283 | 0.72 | HRH3 (0.65) | HRH3ACACBOPRM1OPRD1OPRK1 | |
| SCHEMBL22755424 | 0.72 | HRH3 (0.65) | HRH3ACACBOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |
| US-7314937-B2 | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2008-01-01 | — | — | US | disclosed |