Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532689 | 1.00 | MC4R (0.53) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL6112003 | 0.98 | MC4R (0.51) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL11690784 | 0.94 | DRD2 (0.51) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL4488266 | 0.93 | MC4R (0.48) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL4496003 | 0.92 | MC4R (0.44) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL7794183 | 0.90 | CHRM1 (0.54) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL4476492 | 0.89 | MC4R (0.44) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL4474179 | 0.86 | MC4R (0.41) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL17046111 | 0.85 | TRPV1 (0.47) | MC4RCHRM1KCNH2DRD2DRD3 | |
| SCHEMBL4471201 | 0.85 | TRPV1 (0.41) | MC4RCHRM1KCNH2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |