Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | GHSR | Q92847 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11690784 | 0.97 | DRD2 (0.51) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL6112003 | 0.92 | MC4R (0.51) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL7532689 | 0.90 | MC4R (0.53) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL14288494 | 0.90 | MC4R (0.53) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL4471201 | 0.87 | TRPV1 (0.41) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL17046170 | 0.86 | DRD3 (0.46) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL4493879 | 0.85 | BCHE (0.40) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL17046111 | 0.84 | TRPV1 (0.47) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL4488266 | 0.84 | MC4R (0.48) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A | |
| SCHEMBL4482522 | 0.81 | TRPV1 (0.38) | CHRM1OPRM1SLC6A2SLC6A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1355696-A | Method to aid smoking cessation | KNOLL PHARMACEUTICAL CO (US) | 2002-06-26 | — | — | CN | disclosed |
| EP-1150672-A1 | METHOD TO AID SMOKING CESSATION | KNOLL PHARMACEUTICAL COMPANY (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1150672-A1 | METHOD TO AID SMOKING CESSATION | KNOLL PHARMACEUTICAL COMPANY (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000043002-A1 | METHOD TO AID SMOKING CESSATION | KNOLL PHARMACEUTICAL COMPANY (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000043002-A1 | METHOD TO AID SMOKING CESSATION | KNOLL PHARMACEUTICAL COMPANY (US) | 2000-07-27 | — | — | WO | disclosed |