Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.69 |
| ▸ | PIP4K2C | Q8TBX8 | 4/20 | 0.50 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14289556 | 0.85 | TRPV1 (0.62) | TRPV1PIP4K2A | |
| SCHEMBL14289469 | 0.84 | TRPV1 (0.68) | TRPV1 | |
| SCHEMBL14289494 | 0.84 | TRPV1 (0.81) | TRPV1PIP4K2CPIP4K2A | |
| SCHEMBL14289449 | 0.83 | TRPV1 (0.71) | TRPV1 | |
| SCHEMBL14314172 | 0.83 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL14289448 | 0.83 | TRPV1 (0.68) | TRPV1 | |
| SCHEMBL14289484 | 0.82 | TRPV1 (1.00) | TRPV1PIP4K2CPIP4K2A | |
| SCHEMBL14289495 | 0.81 | TRPV1 (0.70) | TRPV1PIP4K2CPIP4K2A | |
| SCHEMBL3929845 | 0.80 | TRPV1 (0.55) | TRPV1 | |
| SCHEMBL3937481 | 0.80 | TRPV1 (0.59) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004253-A1 | Thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | US | disclosed |
| US-20080004253-A1 | Thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004253-A1 | Thiazolopyrimidine modulators of TRPV1 | TRPV1, TRPA1, TRPV2 | TRPV1 1/4885PIP4K2C 1483/4885PIP4K2A 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.