Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.59 |
| ▸ | MEN1 | O00255 | 11/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.59 |
| ▸ | LMNA | P02545 | 8/20 | 0.59 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063942 | 1.00 | MAPT (0.59) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL14291437 | 0.87 | MAPT (0.58) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL13091221 | 0.83 | MAPT (0.60) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL3063944 | 0.81 | MAPT (0.47) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL3063940 | 0.81 | MAPT (0.47) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL22737807 | 0.74 | MAPT (0.68) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL13942702 | 0.72 | MAPT (0.54) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL8238479 | 0.71 | MAPT (0.61) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL22737384 | 0.71 | MAPT (0.70) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL23345459 | 0.70 | KMT2A (0.72) | MAPTMEN1KMT2ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021250-A2 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING BCL-2 FAMILY MEMBER PROTEINS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2008-02-21 | — | — | WO | disclosed |