Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13091221 | 0.85 | MAPT (0.60) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL29345146 | 0.73 | LMNA (0.94) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL3063942 | 0.72 | MAPT (0.59) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL14291439 | 0.72 | MAPT (0.59) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL13943786 | 0.72 | LMNA (0.58) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL14291437 | 0.72 | MAPT (0.58) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL11810697 | 0.71 | LMNA (1.00) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL3115297 | 0.70 | LMNA (0.77) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL30139086 | 0.70 | LMNA (0.77) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL757098 | 0.70 | LMNA (0.77) | MAPTLMNAHTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194783-B1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM DISCOVERY INC (US) | 2017-07-05 | — | — | EP | disclosed |
| WO-2009023558-A1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM DISCOVERY INC. (US) | 2009-02-19 | — | — | WO | disclosed |