Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1207159 | 0.94 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL14293330 | 0.93 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL14293498 | 0.93 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL12895367 | 0.90 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL14292994 | 0.89 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL14292968 | 0.88 | MAPT (0.38) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL1209650 | 0.87 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL1207775 | 0.86 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 | |
| SCHEMBL14293229 | 0.86 | MAPT (0.36) | ALDH1A1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL1207320 | 0.85 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HPGDKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020045-A1 | TETRAHYDROBENZOTHIOPHENE DERIVATIVES | 4SC AG (DE) | 2008-02-21 | — | — | WO | disclosed |