Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18360948 | 0.82 | MAP4K4 (0.49) | KDRTAOK1MAP4K4CLK2GSK3A | |
| SCHEMBL900339 | 0.82 | MAPT (0.43) | KDRMAP4K4CLK2RPS6KA3MAP4K2 | |
| SCHEMBL900471 | 0.77 | PAK1 (0.47) | L3MBTL1CSNK2A1 | |
| SCHEMBL1901292 | 0.70 | MAP4K4 (0.53) | KDRTAOK1MAP4K4CLK2GSK3A | |
| SCHEMBL869609 | 0.68 | KDR (0.54) | KDRTAOK1MAP4K4CLK2GSK3A | |
| SCHEMBL595121 | 0.68 | GPR35 (0.43) | LCKMAPK14 | |
| SCHEMBL737293 | 0.67 | PI4KA (0.43) | KDRPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15743366 | 0.66 | KDR (0.53) | KDRTAOK1MAP4K4CLK2GSK3A | |
| SCHEMBL18590960 | 0.66 | MAP4K4 (0.49) | KDRTAOK1MAP4K4CLK2GSK3A | |
| SCHEMBL6926673 | 0.66 | KDR (0.49) | KDRTAOK1MAP4K4CLK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044993-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING OR PREVENTING NEURODEGENERATIVE DISEASES OR DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-04-05 | — | — | WO | disclosed |