Sugi Predict

Sugi Predict / Compounds / SCHEMBL3868631

SCHEMBL3868631

SCHEMBL3868631

Nc1ncnc2scc(Cl)c12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAP4K4 O95819 9/20 0.57
▸ CLK2 P49760 9/20 0.57
▸ MAP4K2 Q12851 9/20 0.57
▸ CLK4 Q9HAZ1 9/20 0.57
▸ KDR P35968 8/20 0.57
▸ DYRK1A Q13627 7/20 0.57
▸ GSK3B P49841 6/20 0.57
▸ RPS6KA3 P51812 6/20 0.57
▸ PRKD3 O94806 5/20 0.57
▸ RET P07949 5/20 0.57
▸ LCK P06239 5/20 0.57
▸ MET P08581 5/20 0.57
▸ GSK3A P49840 5/20 0.57
▸ CSNK1A1 P48729 4/20 0.57
▸ ROCK1 Q13464 4/20 0.57
▸ NTRK3 Q16288 4/20 0.57
▸ PRKACA P17612 4/20 0.57
▸ CDK5 Q00535 4/20 0.57
▸ DAPK3 O43293 3/20 0.57
▸ ABL1 P00519 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2185553 0.79 MAPT (0.56) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL869609 0.78 KDR (0.54) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL14293291 0.76 MAP4K4 (0.53) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL15743366 0.76 KDR (0.53) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL1901292 0.76 MAP4K4 (0.53) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL23599237 0.76 MAP4K4 (0.50) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL18590960 0.76 MAP4K4 (0.49) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL3719848 0.76 MAP4K4 (0.62) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL4470227 0.74 KDR (0.55) MAP4K4CLK2MAP4K2CLK4KDR
SCHEMBL4465814 0.73 KDR (0.61) MAP4K4CLK2MAP4K2CLK4KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2026656-B1 INSECTICIDAL METHODS USING 4-AMINO-5-CHLORO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS MERIAL INC (US) 2015-12-23 — — EP claimed
US-8242123-B2 Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds MERIAL LIMITED (US) 2012-08-14 — — US claimed
US-20090203524-A1 Insecticidal Methods Using 4-Amino-5-chloro-thieno[2,3-d]-pyrimidine Compounds BASF SE (DE) 2009-08-13 — — US claimed
CN-101453895-A Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds BASF SE (DE) 2009-06-10 — — CN claimed
EP-2026656-A1 INSECTICIDAL METHODS USING 4-AMINO-5-CHLORO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS BASF SE (DE) 2009-02-25 — — EP claimed
WO-2007135029-A1 INSECTICIDAL METHODS USING 4-AMINO-5-CHLORO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS BASF SE (DE) 2007-11-29 — — WO claimed
WO-2016199761-A1 DIFLUOROMETHYLENE COMPOUNDS 石原産業株式会社 2016-12-15 — — WO disclosed
EP-2026656-B1 INSECTICIDAL METHODS USING 4-AMINO-5-CHLORO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS MERIAL INC (US) 2015-12-23 — — EP disclosed
WO-2015068773-A1 NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND 石原産業株式会社 2015-05-14 — — WO disclosed
CN-101453895-B Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds MERIAL LTD 2012-09-05 — — CN disclosed
CN-101453895-B Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds MERIAL LTD 2012-09-05 — — CN disclosed
US-8242123-B2 Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds MERIAL LIMITED (US) 2012-08-14 — — US disclosed
US-8242123-B2 Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds MERIAL LIMITED (US) 2012-08-14 — — US disclosed
CN-101453895-A Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds BASF SE (DE) 2009-06-10 — — CN disclosed
CN-101453895-A Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds BASF SE (DE) 2009-06-10 — — CN disclosed
CN-101453895-A Insecticidal methods using 4-amino-5-chloro-thieno[2,3-d]-pyrimidine compounds BASF SE (DE) 2009-06-10 — — CN disclosed
EP-2026656-A1 INSECTICIDAL METHODS USING 4-AMINO-5-CHLORO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS BASF SE (DE) 2009-02-25 — — EP disclosed
EP-2026656-A1 INSECTICIDAL METHODS USING 4-AMINO-5-CHLORO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS BASF SE (DE) 2009-02-25 — — EP disclosed
WO-2007135029-A1 INSECTICIDAL METHODS USING 4-AMINO-5-CHLORO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS BASF SE (DE) 2007-11-29 — — WO disclosed
WO-2007135029-A1 INSECTICIDAL METHODS USING 4-AMINO-5-CHLORO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS BASF SE (DE) 2007-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090203524-A1 Insecticidal Methods Using 4-Amino-5-chloro-thieno[2,3-d]-pyrimidine Compounds DDT, ITPR3, ITPR1 MAP4K4 2851/4885CLK2 2605/4885MAP4K2 2587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.